Thursday, August 15, 2019

“La Grande Odalisque” and Manet’s “Olympia” Essay

This essay is comparing paintings of reclining female nudes thru the history of art. – Ingres’ â€Å"La Grande Odalisque† and Manet’s â€Å"Olympia† a Comparison The reclining female nude has been a recurring image in the history of European art. Each artist through time approaches the subject in a different, individualized way. An earlier example of the reclining nude is Giorgione’s â€Å"Sleeping Venus,† created around 1510(see fig. 1). His nude is painted using the clair obscur method with soft, blurred lines, making her fair skin fade slowly into the dark background. Her eyes are closed, giving an aura of innocence, because she is unaware of being observed. Also, Giorgione seems to be experimenting with background in the painting. When examining the painting as a whole, one does not simply see the reclining figure, but the diverse and unusual background also attracts the eye. The fact that the background is open is a certain indication of classical influence on this Renaissance artist. Later, in 1796, Goya began his version of the reclining nude, â€Å"The Nude Maja†(see fig. 2). This painting was ahead of its time, in the respect that the Spanish society was not ready to view this â€Å"obscene† image. She was considered obscene because of her provocative position of frontal nudity, and because this is the first time a nude has been painted in awareness of the painter; her gaze is focused outward. About thirty years later, in 1814, Ingres paints â€Å"La Grande Odalisque†(see fig. 3). She, like Goya’s â€Å"Maja† was rejected at first by society, but for different reasons. She was not rejected because she was â€Å"obscene,† but because her body was an unnatural shape; her long back does not seem proportional to her small head. One critic of Ingres said, â€Å"She has three vertebrae too many!† Ingres’ nude is also looking out from the painting with awareness, as Goya’s â€Å"Maja† did. However, there was not as much objection to the lack of innocence demonstrated here. Her awareness may have been less of an impact  on Ingres’ society because the body of â€Å"La Grande Odalisque† is painted more modestly; it is facing in, away from the viewer. It was also more accepted in Ingres’ society because it was painted after the shock of Goya’s work. The advancement of time has given Europe a chance to broaden its perspectives, and become more open-minded regarding the strict rules of painting nudes. If Ingres’ style in â€Å"La Grande Odalisque† is examined, one can definitely see classical influence playing a large part. The classical influence is most clear through the solid delineation of the figure. There are no blurred or choppy lines. Classical influence is also shown through the way Ingres paints his nude with very smooth, invisible brush strokes. The skin and textures of fabric seem so real, they are practically photographic. She is painted indoors, but the black background behind the blue curtain denotes openness, as seen in classical works. Even though these obvious classical influences exist, Ingres did not follow the classical masters exactly as other Neo-Classical artists did. The figures’ slight deformation does not coincide with the classical challenge to create the perfect body. Why did Ingres reject the classical style when he shaped the body of his nude? Some critics felt that because of her unusual shape, Ingres must have been following the Mannerists, who with their unnatural ways of painting rejected the normal classic figure. However, it is also believed that Ingres elongated the back and outstretched arm to create a more sensual and erotic shape. His painting may also be considered romantic in subject matter, even though his style is Neo-Classical. Almost fifty years after Ingres painted â€Å"La Grande Odalisque,† Manet created â€Å"Olympia†(see fig. 4). Olympia could be considered the most unconventional nude up to this point. She was painted in 1863, and again, society rejected the reclining figure. Olympia was the first of the nudes to give the viewer the sense of a real person, rather than an idealized figure. This realistic, unconventional portrayal caught the world by surpass. Olympia’s pale skin is totally unattractive when compared with the smooth, well-shadowed skin of  Ã¢â‚¬Å"La Grande Odalisque.† Manet’s figure seems two-dimensional, whereas Ingres’ nude is three-dimensional. This is attributed to the fact that Manet, being reluctant to follow the trends before him, â€Å"refused to create three-dimensionality through modeling forms with lines or gradations of color.† â€Å"Olympia† is proof of this refusal; her body almost seems like a cardboard cut-out. Another notable difference between â€Å"Olympia† and the other nudes is her gaze. She looks out at the viewer, just like â€Å"La Grande Odalisque† and â€Å"The Nude Maja,† but where these nudes had very seductive, enjoyable gazes, Olympia’s stare is very honest and frank. She looks out at the viewer with little interest, and she has no modesty whatsoever. This small change in gaze may seem insignificant, but upon examining the various nudes, one can see that it makes a dramatic difference. Manet’s nude, with her uncaring look, has a modernized feeling to it; it clearly demonstrates how Manet got the title, â€Å"The Father of Modern Art.† Throughout the time span of the four paintings mentioned here, it is obvious that the 19th century was indeed the one most revolutionary for new thought and innovation. Ingres’ work at the beginning of that century has not quite reached that point of change, but Manet’s work in the middle of the century reflects a totally new era of change. His art helped the Victorian society to realize that the roller coaster ride into the twentieth century was to be one of exciting, liberal thought. Even today, the reclining nude is being recreated in a very fascinating way(see fig. 5). By a simple comparison of these four works, it is easy to trace the history of art from its classical stage, to the modern art it is today.

Wednesday, August 14, 2019

Merck & Company, Inc: The Recall of Vioxx Essay

Introduction Geroge W. Merck stated once stated, â€Å"We try never to forget that medicine is for the people. It is not for the profits. The profits follow. Initially, Vioxx was the blockbuster drug that Merck needed due to the upcoming Zocor patent cliff in 2006. With an estimated 27,785 heart attacks and sudden cardiac deaths that could have been avoided if Celebrex had been used instead of Vioxx, Merck faces the possibility of not only having to pay enormous civil and criminal penalties, but also losing the trust of patients. Many parties are partially culpable, but Merck faces the severe uphill battle of regaining a reputation that once served as a market differentiator; in the 1980’s, Merck was voted the â€Å"Most Admired Company in American Business† for seven consecutive years. A critical issue in this case is to analyze the events listed in the case and propose an alternate course of action that may help prevent future deaths from other pharmaceutical drugs while not prohibitively restricting innovative research that could potentially save lives if tested properly. Critical Points and Issues Merck was relying on the success of Vioxx due to Zocor’s expiring patent and the direct competition Vioxx was engaged in with Celebrex, which had a first mover advantage. While Celebrex was also a Cox-2 inhibitor, Vioxx was the only Cox-2 inhibitor proven to be beneficial for ulcers and gastrointestinal bleeding. Once studies came out suggesting that Vioxx contributed to a greater number of cardiovascular problems than naproxen, Merck seemed to opportunistically interpret these results. Furthermore, Merck did not institute any studies that might have found negative cardiovascular results, and management failed to perform a study that focused specifically on the cardiovascular risks of Vioxx. Instead, Merck spent a record amount on advertising the gastrointestinal benefit of the drug in a period of uncertainty. The advertising in the time of uncertainty is really unparalleled, and opens the door to questioning (Appendix). Stakeholder Impacts Merck Merck wanted to discover a drug in the Cox-2 inhibitor class that would compete with another class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDS). Cox-2 inhibitors were developed to eliminate the most common side effects of other NSAIDs, ulcers and gastrointestinal bleeding, as an estimated 15,000 people die from GI bleeding annually; Vioxx was designed to treat those high-risk candidates. Vioxx was the only Cox-2 inhibitor proven to have a benefit for ulcers and GI bleeding. Thus, the blockbuster status was created: a stronger drug with a proven benefit for ulcers and gastrointestinal bleeding. As the events unfold in the case, the crucial errors occur prior to the decision to recall the drug on September 30, 2004. After Merck learned that patients had double the risk of heart attack or stroke than if they took placebo and two new competing Cox-2 inhibitors were introduced, Merck decided to pull the drug, but it was already far too late. Dr. Eric Topol, a highly regarded cardiologist conducting research at the Cleveland Clinic, was the first researcher to raise questions about Vioxx. While he concluded that Vioxx produces a risk of heart attack five times greater than naproxen sodium, some believed that Merck’s scientists interpreted the data opportunistically; by saying the difference was due to the protective effect of naproxen, this downplayed the important possibility that Vioxx was contributing to cardiovascular problems. Some scientists say that the protective effect of naproxen argument is implausible, and noted that naproxen would have to be three times as effective as aspirin to account for the difference. While the FDA didn’t buy this argument and issued a warning on all Vioxx labels, many began to wonder if this was the first sign of an unethical deception, cover-up, and manipulation by Merck. Additionally, as the label was added, Merck would later ironically cite the VIGOR study in defense o f Vioxx: it increased the risk only in those patients believe to be a high risk. However, Dr. Gregory D. Curfman, editor of the prominent New England Journal of Medicine noted that it had â€Å"solid evidence that important data on cardiac events was deleted or withheld.† Dr. Curfman argued that the three deleted heart attacks occurred in people who were otherwise at low risk for heart problems, which would ultimately discredit Merck’s claim that is only increased the risk for high-risk patients. The FDA’s mild warning hardly curbed the widespread use of the drug, yet Merck continued to advertise its big benefit to consumers more than any other company in 2000 (Appendx): it causes fewer cases of stomach bleeding. However, this is only a problem for a very small percentage of patients. Thus, there was evidence that hundreds of thousands of people were using the drug that didn’t really benefit from its one advantage. Merck seemed to engage in deceptive marketing practices highlighting this benefit and not the immense risks to compensate for its declining financial situation, nor the fact that the drug was designed specifically for consumers that were in the high-risk gastrointestinal category. In March 2000, management first learned the results from a study of 8,100 rheumatoid arthritis patients that began to take the medication in January. The results from the Vigor study should have alerted management to the potential dangers and risks of using Vioxx. However, since the FDA repeatedly approved the drug, this psychologically this seemed to create the illusion that the drug was safe. While evidence was mounting against the potential risks, in 2000 alone, Merck spent $160 million in direct-to-consumer advertising, the highest that year for all drugs. FDA The FDA has commonly been criticized for requiring superfluous testing. However, others argue that drugs are rushed through testing due to enormous pressure from the drug companies. Even after a drug has been approved, many of the risks are still unknown. The mild warning given by the FDA seemed entirely inappropriate, an action that ultimately prolonged the use of Vioxx for consumers that were not high-risk candidates. In Merck’s defense, it was promoting a product that did in fact reduce pain and gastrointestinal problems; however, it omitted the crucial detail that it increased the risk of cardiovascular problems. The FDA responded by giving Merck a warning, but ultimately, the FDA failed in its ultimate duty to protect the American consumer. Doctors The doctors prescribing the medications failed to sufficiently research the medication and seemed to rely too heavily on the influence of Merck salespeople and/or the general public. If physicians were cognizant that only a small percentage of the population would actually benefit from the fewer gastrointestinal problems, but would expose themselves to a potentially higher risk of developing heart problems, the doctors should have at least informed the patients that NSAIDS might be a safer alternative. The risk-benefit for many patients simply was not justified. The mild warning given by the FDA did not prompt most doctors to research the warning, as essentially all drugs have notable risks. Doctors and patients are also usually affected by the psychological affect of new drugs-these drugs are perceived to be better than existing drugs on the market. Knowing this psychological affect on consumers, the doctors may have felt pressured to prescribe the drug if consumers were asking for it after seeing the advertisements. However, Vioxx was first approved for people with a high risk of GI problems. It is estimated that only about 10% of the prescriptions for Vioxx were most likely for patients that had a high risk of GI problems; the drug was widely overprescribed and was not the optimal treatment for many patients. Patients and Advertising As Merck spent over $500 million advertising Vioxx, many critics try to blame Merck for promoting a product that many believed had a risk that severely outweighed the benefit, especially for patients without a prior history of gastrointestinal problems. An underlying problem in the case is that medicines in America are overused. Many health problems can be avoided by a lifestyle change. Patients need to know that all medications are potentially dangerous and should be used sparingly. However, in the Vioxx case, many consumers were ultimately oblivious about the risk-benefit tradeoff, as it was not mentioned in the advertisements or consultations with physicians. Options and Solution Implementation Considering that Merck adheres to the philosophy of its founder, George Merck, â€Å"medicine is for the people. It is not for the profits,† the course of action taken by modern-day Merck executives followed a path seemingly motivated by financial pressures. The executives seemed to believe that the success of the company was heavily reliant upon Vioxx, and wanted to mitigate any negative associations the drug had with cardiovascular problems. When evidence began to come in showing a potential link between Vioxx and cardiovascular problems, Merck did not run any studies that attempting to reveal the cause of the negative cardiovascular results. Management should have listened to Dr. Deepak Bhatt, a cardiologist at the Cleveland Clinic, who proposed a study of Vioxx in patients with severe chest pain to Merck management. Dr. Bhatt commented at the time â€Å"they {Merck} should have done a trial like this. If they {Merck} internally thought this drug was safe in patients with heart disease, there was no reason not to do it.† Management never ordered a test that would directly explain the results of the clinical trial in 2000. The FDA sent Merck a warning letter for minimizing the serious cardiovascular findings. However, a better option would have been for the FDA to put a black-box warning on Vioxx’s label, or stop the direct-to-consumer advertising until the issue was sorted out. Considering Merck operates under the aforementioned motto, Vioxx was not the optimal treatment for the majority of the patients that took the medication. The patients were not aware of this, and Merck’s aggressive marketing campaign reinforced the belief that this was the proper medication for all patients. Many patients were unnecessarily exposed to a risk due to aggressive marketing tactics when other NSIDS would have been the optimal medication for many patients, not to mention at a lower cost. The government should pay for tests that compare new drugs to older drugs. Many older drugs are simply ignored in favor of newer, heavily advertised drugs. Ultimately, it may take several years following approval for side effects to be exposed-a phenomena that could be avoided altogether if this analysis is done. In addition, the patent life of drugs should be extended. Obviously after this tragedy, drug makers should be required to conduct more studies, but the patent life should be extended to mitigate the pressure to rush drugs to market. Another year of testing means another lost year in terms of patent coverage, and many companies feel pressured to rush drugs to market due to the declining exclusivity period. Bringing a drug to market takes roughly 14 years at a cost of $1.3 billion. If companies are forced to go through additional testing, patent lives should be extended to ensure the incentive for future innovation. Additionally, this could help alleviate the pressure placed upon the FDA to rush drugs to market if companies have longer exclusivity periods, allowing the FDA to conduct additional testing that could potentially prevent future problems. Communication Analysis Vioxx was a medication that was designed to alleviate the gastrointestinal problems for high-risk patients. Vioxx was effective for these high-risk patients that did not have weak hearts. The drug should have never been prescribed to 90% of the patients that received the medication. In the end, some people who shouldn’t have been taking the medication died, and the people who could actually benefit from the medication couldn’t use it because it was pulled from the market. Once preliminary evidence began to mount that there was evidence of this potential link, the aggressive advertising should have stopped immediately. Management should have communicated more clearly to the physicians that this medication was primarily for high-risk patients and articulated the cost/benefit more clearly. In addition, ignoring negative evidence seemed to prove management’s confirmation bias. Management’s deceptive promotion of the drug to increase sales has marred the reputation of a company that may never sufficiently recover. The rigidity of management, unethical, and criminal behavior has tarnished a once respected name.

Tuesday, August 13, 2019

Human Nature and Social values Essay Example | Topics and Well Written Essays - 1000 words

Human Nature and Social values - Essay Example - Custom represents the experiences of men of earlier times as to what they supposed useful and harmful - but the sense for custom (morality) applies, not to these experiences as such, but to the age, the sanctity, the indiscussability of the custom. And so this feeling is a hindrance to the acquisition of new experiences and the correction of customs: that is to say, morality is a hindrance to the development of new and better customs: it makes stupid†.(from Nietzsches Daybreak, s.19, R.J. Hollingdale transl.) 4. The crisis of family values. It is the phenomenon that spreads all over the world. The proof for this is the resolution of the World Family Congress in Prague that was held in 1997 and continues in Geneva in 1999. Here the family crisis was discussed. It is worth mentioning that family crisis is reflected on many spheres of life of any society. Family is the main social institute and guarantee for the moral values. It is a fact that many countries experienced Cultural Revolution, materialism and sexual revolution that caused the discrimination of some aesthetic morals. Then the hedonistic societies were formed. As a result such society gets extramarital relationships, abortions, and unwed mothers. (Smith, 1990) There is a tendency that many young people pay more attention to their work now and they are not family-oriented. Nevertheless it is very difficult to judge as it was mentioned above. Probably now, when people have a special way of life and have firm goals they will be more successful and will not have any historical mistakes in future. (Reamer, 1999) â€Å"What is new, however, is always evil, being that which wants to conquer and overthrow the old boundary markers and the old pieties; and only what is old is good. The good men are in all ages those who dig the old thoughts, digging deep and getting them to bear fruit - the farmers of the spirit. But eventually all land is depleted, and the ploughshare of evil must come

Monday, August 12, 2019

Data collection methods in conducting research of 'Implementation of Essay

Data collection methods in conducting research of 'Implementation of ERP in public sector in Oman - Essay Example A survey in the contemporary environment in which technology identifies modernism therefore identifies suitability of the data collection approach for the proposed study. In addition, management of public sector is centralized with regional headquarters in areas that are considered urban centers. This therefore means that reasonable sample size can be recruited from Oman’s urban centers for implementing the study on the public sector’s application of enterprise resource planning. Implementing the data collection method will involve allocation of research assistants to districts, each research assistant per district. The research assistant will then conduct interview with regional administrators, at their respective districts. The interviews will further target each office in the public sector, such as educational office, health office, agricultural office, among other administrative offices that exist in the assistants’ respective districts. One of the reasons for selection of telephone interviews for data collection is its suitability for the scope of the study that target offices at districts’ major centers in Oman. Consequently, the method will be feasible because of availability of necessary communication facilities. Advantages that the data collection instrument has also support its choice for application in the study. A telephone interview is more flexible that other data collection methods such as mailed questionnaires that may be restricted by schedules and reliability levels of mailing agencies. The flexibility also ensures a mutual time that conveniences both the researcher and the research participants. This further has the advantages of a facilitated response rate and quality of responses because research participants will be more ready and willing to participate in a study that does not inconvenience them. Telephone interview is also

Sunday, August 11, 2019

A critical study of credit risk management in the First Bank of Dissertation

A critical study of credit risk management in the First Bank of Nigeria PLC - Dissertation Example First one is reaction against bank losses from the Newton, it is realized that losses are unbearable after the losses have occurred. The second aspect is that that bank has been pushed by the recent progress in the area of financing securitization, commercial paper and competition with other non-banks to find possible loan borrowers. Big and stable companies have been seen to shift in the open market sources like those in bond markets of finance.The degree of risk of assumed losses can be minimized by organizing and managing the lending criteria with professionalism and also with active approach. Credit risk management issues can be measured if bank could tap progressively refined measuring technique.The adoption of more rigorous credit risk has been facilitated by the technological developments, predominantly the growing availability of low cost computing power and communication. A lot of banks still have a long way to go in the implementation of such new approaches.Competition in t he provision of financial services is increasing probable due to the acceleration of change in credit risk management in the banks which is viewed as an unavoidable response to an environment and, thus need to classify new and gainful business prospects and appropriately measure the related risk is mounting for the banks and other financial institutions. ... When banks extend their credit considering that borrowers will pay back their loan amounts then the extended credit to the borrowers may be at the risk of default, banks income decreases due to the necessity for the provision for the loans as some borrowers usually default. Commercial banks are exposed to an additional risk of variability as they do not have a clue of what proportion of loan borrowers will default. As a matter of fact almost all the financial institutions bear a certain degree of risk when these institutions lend to consumers and to the businesses, hence when certain borrowers fail to repay the loan amount, they experience some loan losses. Credit risk face by a bank has a possibility of loss arising in case of non-repayment of interest or principal or both. Payment delays and the credit risk among procedures can be transferred by the banks and other financial intermediaries (Demirguc-kunt and Huzinga, 2000). Certain techniques are developed for the measurement of th e credit risk which can be linked with pace of evolution (Laker, 2007; McDonough, 1998; Couhy, 2005; Brown, 2004). Different banks are differentiated with their adoption of different credit risk management policies. A bank having assets that constitutes of loans in their portfolio are relatively illiquid and exhibits the highest credit risk (Koch and MacDonald, 2000). According to the asymmetric information, good borrowers and bad borrowers are might be impossible to distinguish, which can result into an adverse selection and moral hazards problems (Auronen, 2003). Due to the adverse selection and moral hazards banks are led to substantial accumulation of non-performing accounts.

Saturday, August 10, 2019

Bill Levitt Essay Example | Topics and Well Written Essays - 1000 words

Bill Levitt - Essay Example Unquestionably, Bill Levitt, whose family had been in the custom home building business, envisioned how this atmosphere of new found prosperity and the lack of adequate housing in the overcrowded cities of the East could pave the way for mass production home construction that would forever change the landscape of America - Suburbia was born. Prior to the post-World War II era home ownership in urban America was primarily reserved for the affluent. Custom home building was the norm and the cost was prohibitive to many people. The vast majority of the urban population lived in cramped apartments and row houses and, for the majority, home ownership was only a dream. Levitt, however, seizing on his experience and knowledge of home building understood that through streamlining the building process and standardizing the home designs, he could mass produce homes affordable to the average family. Levitt, though, went a step further by creating massive housing developments on the outskirts of urban industrial cities which offered the prospect of middle class comforts at a price almost any young family could afford (Hales 1). Levitt did not stop with merely building affordable homes; He astutely created communities within these huge developments that offered the convenience of shopping, recreation, church and schools all designed and created within the developments. Levitt sold more than homes; he sold a new way of life complete with a sense of upward mobility and community to the burgeoning young families of the early 1950's. In order to mass produce affordable homes, Levitt drew on several different sources: the efficiency of assembly line production with interchangeable parts coupled with simplistic architectural designs the emphasized open floor plans and modern conveniences. "Levitt sacrificed individuality and custom design for low-cost efficiency" ('Building' 3). To accomplish this Levitt offered only a few models of home choices in each of his developments. Additionally to save on the cost of construction these single family homes were constructed on slab foundations instead of the traditional basement. He did not skimp on quality, however. All the homes constructed used quality products in the building process and the homes offered modern conveniences that appealed to his target audience of young families looking to own their own home on the outskirts of the urban hubs. A testament to Levitt and Sons Builders was the fact that "between 1950 and 1960, 20 million people were drawn to mass housing d evelopments on the outskirts of America's cities" ('Building' 1). To facilitate the low production costs of his homes, Levitt streamlined every facet of home construction. He assembled groups of workers that performed the same tasks over and over again moving from home to home within the development. One group would prepare the building site. One group would pour concrete. One group would rough frame. One group would apply siding. In short, each and every task had specific workers to complete each specific task. This ensured efficiency, speed, unsurpassed productivity and cost containment previously unheard of in the home building industry. Additionally, as there were limited home models constructed his company saved on material cost by purchasing in bulk. His building plans were so well designed

Web Application development Assignment Example | Topics and Well Written Essays - 3000 words

Web Application development - Assignment Example The people who share same spirits in sports would find this application as a great place for sharing their experiences, giving and taking advises, organizing events etc. This application will use the latest technology and simple yet elegant user interface. The Application allows it user to search people based on their interest in any sports. Search results could be filtered by location when the area of the operation expands in the future. The application will be developed with HTML5 and JavaScript in the front end and PHP in the server side scripting. Initially MySQL could be used as database client as number of users and frequency of interactions are considered. When future functionalities are introduced and website’s hits will be increasing, a more scalable database client such as Cassandra could be used. In this report we are including a detailed timeline for the development of application, design, structure, implementation details and future development ideas. New users can register to our web application through a signup facility. Users are requested to provide an username and password in order to gain full access to Sports pal .Non registered users can access only the homepage contents. User data is only passed through an encrypted SSL connection (Buttyan n.d.: 1). During the registration process Sports pal will collect details such as Full name, Date of Birth, Email address and physical location of the users. These details are displayed in our profile page. User can also update these details even after signing up to our application. These profiles are publicly viewable by all users of the application. Users are requested to add a sport of their interest during signup process and it could be edited in user profile functionality. Users can update their status message logging in to Sports Pal. This is a common featured shared by all social networking websites today. This facility will allow